https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Concentrations of plasma-borne extracellular particles differ between multiple sclerosis disease courses and compared to healthy controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38878 n = 13) erythrocyte-derived (CD235a) extracellular particles were increased, while platelet-derived (CD41b), leukocyte-derived (CD45), and CD4⁺T cell-derived (CD4) extracellular particles were decreased compared to both healthy controls (n = 27) (p<0.05) and secondary progressive multiple sclerosis patients (n = 9) (p < 0.05). Endothelium-derived extracellular particles (CD146) were increased in stable relapsing-remitting multiple sclerosis patients (n = 17) compared to healthy controls (p < 0.05). Extracellular particles from several different cells of origin correlated with each other and clinical parameters (e.g. disease duration, number of relapses, EDSS), though clinical correlations did not withstand corrections for multiple comparisons. Conclusions: Concentrations of erythrocyte-, leukocyte-, and platelet-derived extracellular particles were altered in relapsing multiple sclerosis patients and endothelium-derived extracellular particles were increased in stable relapsing-remitting patients compared to healthy controls. Extracellular particles may provide insights into altered the crosstalk between peripheral blood cells in multiple sclerosis, which may lead to the discovery of novel therapeutic targets.]]> Wed 23 Feb 2022 11:05:08 AEDT ]]> The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: implications for gene function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26643 Wed 11 Apr 2018 13:39:49 AEST ]]> Erythrocytes in multiple sclerosis - forgotten contributors to the pathophysiology? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28831 Wed 11 Apr 2018 13:23:36 AEST ]]> Genome-wide DNA methylation profiling of CD8+T cells shows a distinct epigenetic signature to CD4+T cells in multiple sclerosis patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26346 Wed 11 Apr 2018 13:23:03 AEST ]]> Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32442 Thu 09 Dec 2021 11:04:09 AEDT ]]> The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19680 Sat 24 Mar 2018 07:53:39 AEDT ]]> Genome-wide DNA methylation changes in CD19⁺ B cells from relapsing-remitting multiple sclerosis patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35542 Mon 26 Aug 2019 15:28:04 AEST ]]> Erythrocyte microRNAs show biomarker potential and implicate multiple sclerosis susceptibility genes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46091 Fri 11 Nov 2022 09:31:14 AEDT ]]>